An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling
Membrane contact V-neck sites are regions of close apposition between organelles that facilitate information transfer.Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER).Antagonizing action of the Ca2+-mobilizing messenger NAADP, inhibiting its